Buy PE-22-28 – Peptide Science

PE-22-28 (Spadin Analog) 10mg Overview

PE-22-28 (Spadin Analog) 10mg from Peptide Science is the synthetic 7-amino-acid peptide corresponding to residues 22 to 28 of the sortilin propeptide spadin sequence, supplied as a lyophilised vial for in-vitro neuroscience research. The compound is the shortened active fragment of the longer 17-residue spadin peptide, characterised in published research literature for TREK-1 potassium channel inhibition.

Compound Class and Mechanism

PE-22-28 is the truncated 7-residue active fragment of spadin, the propeptide cleaved from sortilin during maturation. The peptide has been characterised in preclinical research for selective inhibition of the TREK-1 potassium channel, a two-pore-domain K+ channel implicated in cell-culture models of mood-regulatory signalling. The TREK-1 inhibition mechanism is distinct from monoamine-pathway pharmacology, providing a research tool for channel-pathway investigations. Browse the broader nootropic peptide range.

Specifications

For paired research with other CNS-pathway research peptides, see Selank 10mg or P21 (P021) 5mg.

Reconstitution and Handling

The lyophilised vial reconstitutes with bacteriostatic water at the working concentration set by the principal investigator. Aliquoting reconstituted stock for single-use frozen storage is the standard preclinical handling practice for short-sequence peptides.

Quality and Shipping

Each batch passes HPLC at greater than 99 percent purity, with mass-spectrometry identity confirmation. A Certificate of Analysis accompanies every order. Material is filled in a US laboratory under ISO 9001:2015-aligned quality systems and dispatched in temperature-monitored insulated packaging.

For laboratory research and development use only. Not for human or veterinary consumption. Has not been evaluated by the U.S. Food and Drug Administration and is not intended to diagnose, treat, cure, or prevent any disease. Purchasers acknowledge they are qualified researchers age 21 or older and accept responsibility for compliance with all applicable federal, state, and local laws.